Solid Tumors
Conditions
Interventions
Index test:Targeting FAP probes PET/CT imaging
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Criteria for selecting cases Subjects who also meet the conditions of (1) or (2), (3) and (4) were selected for this study. (1) Gender-limited, age 18-80 years old; (2) Patients with suspected or newly diagnosed or treated malignant tumors (supporting evidence includes MRI, CT, tumor markers and pathological reports); (3) Non-tumor diseases such as inflammatory lesions, fibrosis, Ig4-related diseases, atherosclerotic plaque, rheumatoid arthritis and myocardial remodeling; (4) Patients who arrange 18FDG and radionuclide marker FAPI (68Ga-FAPI, 18F-FAPI, FATT, etc.) PET/CT or PET/MR scans at the same time; (5) Patients who can provide informed consent (signed by participants, parents or legal representatives) and agree in accordance with the guidelines of the Clinical Research Ethics Committee. Criteria for selection of healthy subjects: (1) regardless of gender, age of 18-80; (2) no history of major diseases and surgery; (3) normal blood routine, liver and kidney function; (4) subjects who can provide informed consent (signed by participants, parents or legal representatives) and agree in accordance with the guidelines of the Clinical Research Ethics Committee.
Exclusion criteria
Exclusion criteria: (1) Those with severe cardiovascular and cerebrovascular diseases; those with liver and kidney insufficiency; (2) Pregnant or breastfeeding; (3) Claustrophobia; (4) Drug and/or alcohol abusers, people with a history of contrast agent or other drug allergies; (5) There are MRI scan contraindications. (5) prior history of severe allergy, or allergy to any active or inactive ingredient of the investigational drug; (6) Insufficient venous access; (7) The researchers judged that it was not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of lesions;Maximum Standard Uptake Value (SUVmax);location of lesion;size of lesion;sensitivity;specificity;positive predictive value;Diagnostic efficacy of cancer; | — |
Countries
China
Contacts
Public ContactPengcheng Ran
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed