Acute Respiratory Distress Syndrome (ARDS)
Conditions
Interventions
Gold Standard:The Berlin Definition of Acute Respiratory Distress Syndrome (ARDS)
Index test:The new global definition of ARDS published online in the American Journal of Respiratory and Critical Care Medicine on May 24, 2023.
Sponsors
The Second Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Retrospective study section: 1. Age = 18 years; 2. Diagnosed with ARDS, meeting either the Berlin criteria or the new global criteria; 3. Not intubated, with HFNO = 30 L/min, or under non-invasive ventilation (NIV)/continuous positive airway pressure (CPAP) with PEEP = 5 cmH2O; 4. Hypoxemia: PaO2/FiO2 = 300 mmHg or SpO2/FiO2 = 315 mmHg with SpO2 = 97%; 5. Chest X-ray or CT showing bilateral dense opacities, or ultrasound showing bilateral B-lines and/or consolidation, which cannot be fully explained by pleural effusion, lung lobe collapse/atelectasis, or nodules. Prospective study section: 1. Age = 18 years; 2. Patients admitted to the ICU who are at high risk of developing ARDS.
Exclusion criteria
Exclusion criteria: Retrospective study section: 1. Hospitalization or survival time not exceeding 24 hours; 2. Congestive heart failure; 3. Cardiogenic pulmonary edema; 4. Pulmonary hypertension; 5. Large pleural effusion; 6. Extensive lung lobe collapse/atelectasis; 7. Missing PaO2, FiO2, or SpO2 data; 8. Missing PEEP data; 9. Patients not using high-flow oxygen or NIV/CPAP, and those with more than 30% missing data for variables, were excluded from the variable selection process. Prospective study section: 1. Hospitalization or survival time not exceeding 24 hours; 2. Diagnosed with ARDS upon hospital admission or ICU admission; 3. Presence of severe comorbidities, such as severe heart failure, end-stage COPD, untreated or uncontrolled pulmonary hypertension, or late-stage lung cancer or widely metastatic pulmonary tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy and Consistency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Applicability; | — |
Countries
China
Contacts
Public ContactTian Baoping
The Second Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed