Parkinson's Disease
Conditions
Interventions
Sponsors
Renmin hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Voluntary signing of informed consent form Promise to comply with research procedures and cooperate in implementing the entire research process The diagnosis of PD is consistent with ? slow movement, slow initiation of voluntary movement, and progressive decrease in the speed and amplitude of repetitive movements; ? At least one of the following symptoms: muscle rigidity, resting tremor (4-6Hz), postural balance disorder (not caused by primary visual, vestibular, cerebellar, or proprioceptive disorders)
Exclusion criteria
Exclusion criteria: 1.Presence of late-stage, severe, or unstable other internal medical conditions affecting brain function assessment. 2.History of acute cerebrovascular events in the past 3 months. 3.Active epilepsy. 4.History of psychiatric disorders (depression, anxiety, delirium). 5.Conditions such as aphasia, delirium, or impaired consciousness affecting freezing assessment. 6.Individuals who have undergone intracranial surgical treatment for Parkinson's disease. 7.Lack of cooperation or inability to effectively complete the trial during the experimental process. Participants undergoing treatment should discontinue all anti-Parkinson's disease medications for at least 12 hours before the examination to minimize the potential impact of medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Magnetic Resonance Imaging (fMRI), Structural Magnetic Resonance Imaging (sMRI) of cerebral cortex;Clinical information; | — |
Secondary
| Measure | Time frame |
|---|---|
| Magnetic resonance imaging of the cerebellum and various cerebellar lobes; | — |
Countries
China
Contacts
Public ContactHuaguang Yang
Renmin Hospital of Wuhan University
Outcome results
None listed