depression
Conditions
Interventions
MD:None
Sponsors
The First Af?liated Hospital of Xi’an Jiaotong University
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Age 16-60 years old, male or female; (2) Meet the diagnostic criteria for depression in the International Classification of Diseases-10 (ICD-10), and the Hamilton Depression Scale (HAMD) score =18 points; (3) Junior high school education and above, can cooperate with the completion of relevant scales and sample collection; (4) did not receive antidepressant therapy at admission or took medication for less than 14 days; And the duration of drug withdrawal =3 months; (5) No history of infection and taking hormones, antibiotics or anti-inflammatory drugs in the past 1 month; (6) History of physical diseases such as centerless, liver, kidney and gastrointestinal tract, active infection, active or chronic inflammation, autoimmune diseases, etc.
Exclusion criteria
Exclusion criteria: (1) Pregnant and lactating women; (2) Clinically significant or unstable medical conditions, including congestive heart failure, liver and kidney failure, cancer, immune and metabolic endocrine diseases; (3) Patients with acute or chronic infection, taking anti-inflammatory drugs, cortisol hormones, and receiving antibiotics for 3 consecutive days in the past 1 month; (4) Patients with neuropsychiatric diseases other than depression.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scores of Hamilton Depression Scale;Scores of Hamilton Anxiety Scale;PHQ-9;GAD-7;Thinc-it;GSRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sheehan Disability Scale;PSQI; | — |
Countries
China
Contacts
Public ContactMin Jia
The First Af?liated Hospital of Xi’an Jiaotong University
Outcome results
None listed