pneumonia
Conditions
Interventions
Gold Standard:Results of drug sensitivity in traditional bacterial culture
Index test:LAMP+Xpert Carba-R
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Source of cases: All patients with clinically diagnosed HAP/VAP. Inclusion criteria: Clinically diagnosed patients with HAP/VAP (which can be combined with infection at other sites), the diagnostic criteria are as follows: Chinese Guidelines for the Diagnosis and Treatment of Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia in Adults (2018 edition) The American Society of Infectious Diseases and the American Thoracic Society 2016 Clinical Practice Guidelines for the Management of Hospital-acquired and ventilator-associated Pneumonia in Adults HAP: not in the incubation period of pathogen infection before treatment, pneumonia occurred 48 hours after hospitalization; VAP: Usually refers to the lung infection caused by tracheotomy or intubation after 48 hours of mechanical ventilation treatment in patients who did not originally have a lung infection. Because of the subjectivity and uncertainty of this definition, the actual diagnosis process is usually based on clinical and microbiological criteria. Diagnostic criteria: Chest X-ray or CT showing new or progressive solid shadows, infiltrating shadows, or ground glass shadows with 2 or more of the following: (1) Body temperature >38?; (2) purulent airway secretions; (3) Peripheral blood white blood cell count >10×10^9/L or <4×10^9/L.
Exclusion criteria
Exclusion criteria: (1) Under 18 years of age; (2) AIDS; (3) in the pregnancy or lactation period; (4) Have participated in relevant clinical trials; (5) The patient died or was discharged before the first respiratory specimen culture results were released; (6) Known to be severely allergic to commonly used carbapenem-resistant bacterial infection treatment drugs or have been used for more than 96 hours; (7) Previously there were commonly used carbapenem-resistant bacterial infections to treat drug-induced seizures; (8) Those who have not previously received carbapenem therapy and have been diagnosed with epilepsy requiring antiepileptic therapy Patients are also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specificity;positive predictive value;negative predictive value; | — |
Secondary
| Measure | Time frame |
|---|---|
| hospital stays;cost;30-day mortality; | — |
Countries
China
Contacts
Public ContactShuyun Xu
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed