postoperative delirium
Conditions
Interventions
Active stimulation group:The active stimulation group received active electrical stimulation to the left cymba conchae area of the ear. The stimulation frequency was 40 Hz, with a pulse width of 550 µ
Sham stimulation group:The sham stimulation group received electrical stimulation to the left earlobe area. The stimulation frequency was 40 Hz, with a pulse width of 550 µs, and a cycle of 50 seconds
Sponsors
the Second Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age = 65 years, < 85 years 2. Undergoing elective/urgent non-cardiac surgery,the expected surgery duration is =1 hour, and the hospital stay is =3 days. 3. ASA: I~III 4.Clear consciousness, able to communicate normally 5.Informed about and willing to participate in this study
Exclusion criteria
Exclusion criteria: 1. Diagnosed with delirium before surgery, or a history of confirmed neurological or psychiatric disorders; 2. Severe liver, kidney, heart, or lung dysfunction; 3.History of severe trauma or major surgery within the past year; 4. History of drug dependence or alcohol abuse; recent use of cholinergic, anticholinergic drugs, or steroids; 5. Local skin rash, infection, lesions, ulcers, or scars at the stimulation site; 6. History of implanted stimulators, cochlear implants, or metal implants in the body (excluding dental implants); 7. History of unilateral or bilateral vagus nerve injury; 8. Heart rate < 60 beats per minute; 9. Participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium(POD) incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of POD; Postoperative sleep quality;Pain; TNF-a level in peripheral blood;IL-6;IL-1ß; | — |
Countries
China
Contacts
Public ContactJi Muhuo
The Second Affiliated Hospital of Nanjing Medical University
Outcome results
None listed