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Clinical significance of DNA methylation detection in the overall management of cervical lesions

Clinical significance of DNA methylation detection in the overall management of cervical lesions

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400090648
Enrollment
Unknown
Registered
2024-10-10
Start date
2024-10-10
Completion date
Unknown
Last updated
2024-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical lesion

Interventions

Gold Standard:Cervical lesions: including precervical lesions (LSIL/HSIL) and cervical invasive carcinoma
The diagnosis of previous cervical lesions should be preceded by routine cervical cancer screening methods, which are mainly HPV preliminary screening alone or combined HPV+TCT screening. If the initi
Index test:Differentiated DNA methylation sites were screened from common cervical exfoliated cells of normal population and patients with different levels of cervix, and verified in expanded samples

Sponsors

Jingzhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) =18 years old, =65 years old, (2) no history of cervical disease diagnosis and surgical treatment, (3) no history of other malignant tumors, (4) no recent history of vaginitis and treatment, (5) complete clinical case data, (6) informed consent of the patient;

Exclusion criteria

Exclusion criteria: Immunosuppressive drug treatment, lactation, complicated with other serious immune system disease or major disease, recent 2 days of sexual history.

Design outcomes

Primary

MeasureTime frame
Accuracy;Sensitivity;Specificity;

Countries

China

Contacts

Public ContactYong Zeng

Jingzhou First People's Hospital

349213101@qq.com+86 181 6313 2858

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026