Mental disorder
Conditions
Interventions
Health Control Group:No interventions, not applicable.
Schizophrenia Group:No interventions, not applicable.
Mood Disorder Group:No interventions, not applicable.
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
16 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Willing to sign an informed consent form; 2. Commit to comply with the research procedures and cooperate with the implementation of the entire study; 3. Age between 16-45 years old; 4. For the schizophrenia group or mood disorder group, they should meet the diagnostic criteria for schizophrenia or mood disorders in the "Diagnostic and Statistical Manual of Mental Disorders (DSM-5)"; for the healthy control group, they should be evaluated by at least two attending psychiatrists and have no history of any psychiatric illness or family history. 5. If it is a woman of childbearing age, she should use contraception for at least one month before screening and commit to using contraception throughout the entire study and continue until the specified time after the study ends.
Exclusion criteria
Exclusion criteria: 1. Subjects who have taken vitamins, nonsteroidal anti-inflammatory drugs, or corticosteroids that may affect prostaglandin metabolism in the past two weeks; 2. Patients with chronic sleep disorders; 3. History of alcohol or drug abuse or dependence on psychotropic substances; 4. Pregnant or lactating women; 5. Meet the diagnostic criteria for intellectual disability in the DSM-V; 6. Patients with organic brain diseases or other unstable or severe physical diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenated hemoglobin concentration;Deoxyhemoglobin concentration;Transient receptor potential vanilloid type 1 channel, TRPV1;sirtuin-3, SIRT3;Positive and Negative Syndrome Scale, PANSS;Hamilton Anxiety Scale, HAMA;Brief Assessment of Cognition in Schizophrenia, BACS;Montgomery-Asberg Depression Rating Scale, MADRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Superoxide Dismutase 2, SOD2;Inflammatory factor;Bech-Rafaelsen Mania Rating Scale,BRMS;Eye Basic Emotion Discrimination Task, EBEDT;Faux pas recognition; | — |
Countries
China
Contacts
Public ContactHuiling Wang
Renmin Hospital of Wuhan University
Outcome results
None listed