lung cancer
Conditions
Interventions
Propofol group:Propofol was injected 4 ~ 12mg/(kg·h) intravenously, and BIS was maintained at 40~60
Low dose remimazolam group:Remimazolam toluenesulfonate was injected 0.2mg/(kg·h) intravenously. The dosage of propofol was adjusted according to BIS, and the BIS was maintained at 40-60 during the op
High dose remimazolam group:Remimazolam toluenesulfonate was injected 0.4mg/(kg·h) intravenously. The dosage of propofol was adjusted according to BIS, and the BIS was maintained at 40-60 during the o
Sponsors
Liaoning Cancer Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) All met the diagnostic criteria for lung cancer; (2) Age =65 years old; (3) Body mass index (BMI) 18-28kg /m2; (4) American Society of Anesthesiologists (ASA) Grade I ~ III; (5) All underwent thoracoscopic lobectomy; (6) All signed informed consent
Exclusion criteria
Exclusion criteria: (1) Serious dysfunction of heart, lung, brain, liver, kidney and other organs; (2) Patients with coagulation dysfunction (3) patients with other types of malignant tumors; (4) There is a history of cognitive impairment or mental illness and other inability to partner; (5) long-term use of sedative or analgesic drugs, opioid dependence or tolerance, a history of drug use; (6) Those who have a history of allergy or contraindication to the anesthetic used; (7) Patients with a history of thoracoscopic surgery; (8) Patients undergoing thoracotomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of intraoperative hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic index;Indicators of postoperative cognitive dysfunction;Recovery quality index in awakening period;Incidence of various adverse reactions; | — |
Countries
China
Contacts
Public ContactWang Mingyu
Liaoning Cancer Hospital
Outcome results
None listed