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The effect of periorbital intense pulsed light irradiation on ocular surface microvascular regeneration and allergic inflammation

The effect of periorbital intense pulsed light irradiation on ocular surface microvascular regeneration and allergic inflammation - Inhibition of ocular surface angiogenesis and allergic inflammation by IPL

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400090617
Enrollment
Unknown
Registered
2024-10-10
Start date
2024-10-15
Completion date
Unknown
Last updated
2024-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergic conjunctivitis

Interventions

experimental group:IPL treatment + artificial tears + anti-allergic drugs
control group:Artificial tears + anti-allergic drugs

Sponsors

Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Recruitment and enrollment 1) With eye-itching, accompanied by foreign body sensation and increased conjunctival secretion; 2) With conjunctival hyperemia, conjunctival papilla,or specific corneal lesion, at least one of the above; Allergic conjunctivitis can be diagnosed if the above two conditions are met at the same time. 3) The PAC patients were screened according to the 2018 expert consensus diagnostic criteria, and then the moderate to severe PAC patients were selected according to the ocular allergic signs grading scale. 4) continuous attack within the past 3 months, and no use of relevant anti-allergic and hormone drugs or other desensitization treatment within the past 2 weeks. 5) The patients who met the above criteria were randomly divided into IPL treatment group and control group. The patients in IPL treatment group were given IPL treatment + artificial tears + anti-allergic drugs. The control group was only treated with artificial tears and anti-allergic drugs.

Exclusion criteria

Exclusion criteria: Patients with recent eye infection, bleeding or other local diseases, and topical use of anti-allergic and hormone drugs; Patients with ocular pterygium, scar, trichiasis, periocular acne, eyelid dysraphism, eyelid entropion, tumor and other ocular surface structures; Patients with a history of ocular local surgery; Wearing contact lenses; Patients with major chronic diseases include but are not limited to those with cardiopulmonary diseases, diabetes, mental disorders, etc.; Women in pregnancy.

Design outcomes

Primary

MeasureTime frame
Subjective visual analogue scale (VAS) of symptoms;

Secondary

MeasureTime frame
Red eye analysis;Assesment of AC signs;

Countries

China

Contacts

Public ContactLi Dan

Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong

lidan@jsiec.org+86 137 2926 2500

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026