Stress response
Conditions
Interventions
Group R1:Remifentanil 2ug/kg was used for anesthesia and analgesia
Group R2:Remifentanil 3ug/kg was used for anesthesia and analgesia
Group R3:Remifentanil 4ug/kg was used for anesthesia and analgesia
Sponsors
The Peoples' Hospital of Jianyang city
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) 18 <= age <= 60 years; (2) Non-cardiac selective surgery; (3) ASA Level I-III; (4) Patients who underwent tracheal intubation general anesthesia; (5) Patients who known and agreed to participate in this study, and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients who combined with hypertension, diabetes, coronary heart disease; (2) Patients who combined with HPA-related endocrine diseases; (3) Patients who combined with mental illness or mental disorder; (4) Patients with severe malnutrition, anemia, abnormal liver function; (5) Patients with special conditions such as allergies occured during the induction of anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage change in cortisol (Cor) levels after endotracheal intubation (T1) and before surgical incision (T2); | — |
Secondary
| Measure | Time frame |
|---|---|
| ACTH values of patients at T0 (before anesthesia), T1, T2;Blood glucose values in patients at T0, T1 and T2;Patients' baseline HR, SBP/DBP (MAP);Tracheal intubation time (from opening to fixing tracheal catheter);The morphine equivalent dose of opioid sumption in a patient's induction of anesthesia;Percentage of postoperative and pre-operative leukocyte changes in patients; | — |
Countries
China
Contacts
Public ContactYan Weng
The Peoples' Hospital of Jianyang city
Outcome results
None listed