Sleep disorders
Conditions
Interventions
DEX group (group D):The patients in group D are given dexmedetomidine nasal spray 1 µ g/kg by the professional scientific research staff at 20:00 every night
The nasal spray of the drug ended 1 day before the patient is discharged from hospital.
Observation group (group O):The patients in group O are given saline nasal spray by the professional scientific research staff at 20:00 every night
The nasal spray ended 1 day before the patient is discharged from hospital.
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Elderly patients aged 65 years or older who are scheduled to undergo laparoscopic radical surgery for lung cancer with the first general anesthesia double lumen endotracheal intubation; 2) Gender is not limited; 3) BMI index of 18-30 kg/m2; 4) ASA grades II to III; 5) Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients with congenital heart disease, hypertension, and epilepsy; 2) People with obstructive sleep apnea hypopnea syndrome (OSAHS), depression, or those taking sedatives and analgesics; Cysts, tumors, or polyps in the respiratory tract; 3) Individuals with a history of upper respiratory tract infections in the past 2 weeks, who are unable to cooperate due to hearing or speech impairments or a combination of both, and who refuse to register; 4) Unplanned secondary surgery and transfer to ICU by PACU after surgery; Transfer from the ward to the ICU after surgery; 5) Individuals who have experienced unstable angina or myocardial infarction within the past 3 months; Patients with NYHA functional class = 3; 6) Diabetes patients with complications (diabetes ketoacidosis, hypertonic coma, various infections, macroangiopathy, diabetes nephropathy, retinopathy, diabetes cardiomyopathy, diabetes neuropathy, diabetes foot, etc.); 7) Individuals with severe liver and kidney dysfunction (severe liver dysfunction: one of ALT, conjugated bilirubin, AST, ALP, total bilirubin>2 times the upper limit of normal); Severe renal dysfunction: Cr clearance rate177 umol/L); 8) Participated in other clinical trials within the 3 months prior to enrollment in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pre medication anxiety and depression scale and Athens Sleep Inventory (AIS) scores, as well as pre medication, preoperative, and postoperative sleep quality scores at 24, 48, and 72 hours.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative tracheal intubation reaction and opioid dosage.;Acute pain, opioid dosage, nausea and vomiting, cognitive function, and delirium at 24, 48, and 72 hours postoperatively.;Chronic pain, sleep quality, and long-term quality of life at 3, 6, 9, and 12 months postoperatively.; | — |
Countries
china
Contacts
Public Contactlibing
Henan Provincial People's Hospital
Outcome results
None listed