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The impact of local immune microenvironment on the regeneration process of repaired tissue in talar osteochondral lesions treated by different bone marrow stimulation procedures

The impact of local immune microenvironment on the regeneration process of repaired tissue in talar osteochondral lesions treated by different bone marrow stimulation procedures

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400090571
Enrollment
Unknown
Registered
2024-10-08
Start date
2024-10-08
Completion date
Unknown
Last updated
2024-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Talar osteochondral lesion

Interventions

Arthroscopic microfracture procedure(Group A):A standard arthroscopic microfracture procedure will be performed
Arthroscopic microfracture procedure augmented with autologous iliac bone marrow(Group B):A arthroscopic microfracture procedure augmented with autologous iliac bone marrow will be performed.
Arthroscopic microfracture procedure augmented with autologous platelet-rich plasma(Group C):A arthroscopic microfracture procedure augmented with autologous platelet-rich plasma(PRP)will be performed

Sponsors

General Hospital of Central Theater Command
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1) Age from 18 to 50 years old; 2) Diagnosed with talar osteochondral lesions based on the medical history, physical examination, and imaging studies; 3) Size of the talar osteochondral lesion: diameter = 10mm, depth = 5mm; 4) Normal lower extremity alignment; 5) Body mass index (BMI) < 30; 6) Patients who volunteer to participate and have signed an informed consent form;

Exclusion criteria

Exclusion criteria: 1) Revision surgeries; 2) Rheumatoid arthritis or osteoarthritis; 3) Bleeding tendencies or coagulation disorders; 4) Local infections around the ankle; 5) Diabetes mellitus; 6) Abnormal lower extremity alignment; 7) Patients with mental or psychological illnesses or consciousness disorders that prevent an objective and effective evaluation of functional status; 8) Patients who refuse to undergo related examinations.

Design outcomes

Primary

MeasureTime frame
The Foot and Ankle Ability Measure scales (FAAM);Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) 2.0 scores;

Countries

China

Contacts

Public ContactWEI SHIJUN

General Hospital of Central Theater Command,

wsj1974@yeah.net+86 133 9719 5855

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026