Petroclival meningioma
Conditions
Interventions
experimental group:preoperative lumbar drainage
control group:no preoperative lumbar drainage
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) The ages between of 18 and 75 (including critical values), regardless of gender (2) Meningioma diagnosed firstly through imaging (preoperative enhanced MRI), pathologically confirmed (WHO Central Nervous System Tumor Classification, 5th edition 2021), with surgical indications, not involving the temporal lobe on the surgical side, suitable for anterior petrosal approach (evaluated by the operator based on imaging data) (3) with normal language and no accompanying epilepsy in preoperation (4) KPS score = 70 points (5) Expected survival time = 6 months; (6) Having normal organs and hematopoietic function, normal laboratory tests, and no serious surgical contraindications such as heart, lung, liver, kidney dysfunction, and immune deficiency (7) Voluntarily participate in clinical research and sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Excluding intracranial synchronous radiotherapy and chemotherapy (TMZ dosage = 75mg/m2 in synchronous radiotherapy and chemotherapy, radiotherapy dosage is limited to the range of 50-60Gy) (2) Patients receiving treatment with other anti-tumor drugs (including chemotherapy, targeted drugs, immunotherapy, traditional Chinese medicine anti-tumor therapy, electric field therapy, etc.) (3) Individuals who suffer from severe heart disease within the 6 months prior to enrollment, such as unstable angina, myocardial infarction, heart failure (New York Heart Association heart function classification>Grade II), or stroke (excluding lacunar infarction), and unable to tolerate surgery (4) Merge other intracranial tumors such as NF2, multiple meningiomas, brain metastases, or other diseases that damage brain, such as cerebral hemorrhage, cerebral infarction, intracranial infection, etc (5) Previously underwent craniotomy surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Temporal lobe injury; | — |
Countries
China
Contacts
Public ContactXin-ru Xiao
Xuanwu Hospital, Capital Medical University
Outcome results
None listed