interstitial cystitis
Conditions
Interventions
Control group:placebo
Sponsors
Wuxi No.2 People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Interstitial cystitis a)age above 18 years old; b)Interstitial cystitis was diagnosed by clinical examination and diagnosis; c)patients who failed to respond to conventional treatment or had recurrent attacks; d)patients voluntarily participated in the treatment of intestinal flora transplantation and signed the informed consent; e) Patients had not received intestinal microbiota transplantation; f) be conscious and able to communicate in language normally. Donors a)Healthy female, aged 18-30 years, with no intestinal bacterial or fungal infectious diseases in the past three years, healthy work and rest, no bad living habits such as staying up late, and no use of antibiotics, probiotics or immunomodulators in the past six months; b)No history of drug and food allergy, no history of long-term medication; c)No underlying diseases, autoimmune diseases, parasitic infections and other disease states.
Exclusion criteria
Exclusion criteria: Interstitial cystitis a)Suffering from severe cardiovascular and cerebrovascular diseases, respiratory system diseases, immune system diseases and severe liver and kidney damage; b)Suffering from severe mental illness, such as depression, generalized anxiety disorder, etc.; c)Patients with intestinal infection or other infectious diseases; d)Patients with allergic reactions to gut microbiota transplantation; e)Patients with intestinal tumors or other intestinal diseases; f)Patients who failed to provide complete medical history or examination data; g)For various reasons, all kinds of tests were not available for this study. h)Fever, pregnancy, lactation, severe systemic infection, etc.; i)Antibiotics used in the last 2 weeks; j)Use of probiotics or immunomodulatory agents in the past 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| leukocyte;C-reactive protein;Urine analysis;16S rRNA sequence;Questionnaire;Urinary IgA;Amplification and quantitative culture of urine and feces were performed;Mass spectrum identification;Metagenome;Cystoscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| glycosylated hemoglobin;Blood lgA;Liver function;Endotoxin;Infectious disease indicators; | — |
Countries
China
Contacts
Public ContactFeng Ninghan
Wuxi No.2 People's Hospital
Outcome results
None listed