Observation on the analgesic effects of intercostal nerve block and paravertebral block with bupivacaine liposome in patients undergoing thoracoscopic surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400090505

Enrollment

Unknown

Registered

2024-10-08

Start date

2024-10-08

Completion date

Unknown

Last updated

2024-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung space occupying lesion

Interventions

Bupivacaine liposome intercostal nerve block group:Intercostal nerve block with bupivacaine liposome before anesthesia induction

Bupivacaine liposome single-injection paravertebral block group:Single-injection paravertebral block with bupivacaine liposome before anesthesia induction

Bupivacaine liposome double-injection paravertebral block group:Double-injection paravertebral block with bupivacaine liposome before anesthesia induction

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Scheduled for thoracoscopic unilateral lung surgery under general anesthesia with double-lumen endobronchial intubation; 2. Age 18-65 years old; 3. ASA grade: I-III; 4. BMI: 18-28kg/m2; 5. Obtain informed consent from the patient and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Contraindications to nerve block (infection or tumors at the puncture site; unclear or abnormal anatomical location of the puncture site; coagulation dysfunction; allergy to local anesthetics); 2. ICU admission after surgery; 3. Severe cardiovascular and pulmonary disease (organic heart disease; severe arrhythmia; cardiac function class ?-?; acute exacerbation of chronic obstructive pulmonary disease; FEV1 less than 30% of predicted value, etc.); 4. Severe hepatic and renal insufficiency; 5. Poor managed hypertension or diabetes; 6. A history of chronic pain or opioid abuse; 7. Mental illness; 8. Unable to communicate due to illiteracy, speech impairment, or significant hearing or vision impairment.

Design outcomes

Primary

Measure	Time frame
Block range;	—

Secondary

Measure	Time frame
Time required for nerve block;MAP and HR at different time points in the perioperative period;VAS score at rest and on coughing;Cumulative consumption of morphine during the perioperative period;Postoperative QoR-15 score;Nerve block related complications;Postoperative length of hospital stay;	—

Countries

China

Contacts

Public ContactCunming Liu

The First Affiliated Hospital of Nanjing Medical University

cunmingliu@njmu.edu.cn+86 139 5189 0866

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026