Stroke
Conditions
Interventions
Intervention group.:After receiving the standard dose of rt-PA intravenous thrombolysis, the intervention group was given HBO therapy (treatment in a hyperbaric chamber at 2.0 ATA and 100% O2 for 1 ho
Control group.:After receiving the standard dose of rt-PA intravenous thrombolysis, the intervention group was given NBO therapy (treatment in a normobaric chamber at 1.0 ATA and 100% O2 for 1 hour, o
Sponsors
Xining Third People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Native plateau residents aged 18-80 years; 2 within 6 hours of onset; 3 Acute ischemic stroke confirmed by CT or MR; 4. The signs of brain damage persisted for more than one hour and were more serious; 5 Brain NCCT has ruled out intracranial hemorrhage, and there is no early massive cerebral infarction imaging changes.
Exclusion criteria
Exclusion criteria: 1. Previous intracranial hemorrhage, including suspected subarachnoid hemorrhage; (2) a history of intracranial trauma in the past 3 months; 3. Gastrointestinal or urinary tract bleeding within the last 3 weeks; 4. Major surgical operation within the last 2 weeks; 5. Puncture of large arteries in areas not easy to compress hemostasis within the past week; 6. History of cerebral infarction or myocardial infarction within the past 3 months, excluding old small lacunar brain Infarction without signs of neurological deficit; 7. Patients with severe heart, liver, kidney dysfunction or severe diabetes mellitus; 8. Evidence of active bleeding or trauma (e.g., fracture) on physical examination; 9. Oral anticoagulants and INR > 1.5; Heparin therapy (APTT ultrasonographic) within 48 hours Out of normal range). 10. Platelet count less than 100×109/L; 11. Blood glucose 180mmHg (1 mmHg=0.1333 kPa), diastolic pressure > 100 mmHg; 13. Pregnancy; 14. Not cooperating; 15. Mechanical thrombectomy was performed to bridge the patient after intravenous thrombolysis; 16. Relative/absolute contraindications of hyperbaric oxygen therapy: pneumothorax, multiple rib fractures, and open chest Trauma, cavitary pulmonary tuberculosis, retinal detachment, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mRS score at 90 days post-onset.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The NIHSS score at 90 days post-onset.;Symptomatic intracranial hemorrhage.;The degree of improvement of mRS Score at 90 (±7) days; | — |
Countries
China
Contacts
Public ContactXiqiang Zhang
Xining Third People’s Hospital
Outcome results
None listed