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The Diagnostic and Therapeutic Role of Klotho in Sepsis-Associated Encephalopathy and Its Mechanism Research

The Diagnostic and Therapeutic Role of Klotho in Sepsis-Associated Encephalopathy and Its Mechanism Research

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400090497
Enrollment
Unknown
Registered
2024-10-06
Start date
2024-10-06
Completion date
Unknown
Last updated
2024-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis-Associated Encephalopathy

Interventions

Sponsors

The second hospital of hebei medical university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Age = 18 years old; (2) All septic patients who meet the sepsis 3.0 diagnostic criteria; (3) The patient or their family must sign the informed consent form for study enrollment. Note: The diagnostic criteria for sepsis according to the "International Consensus on Definitions for Sepsis and Septic Shock, Third Edition (sepsis-3)" are: suspected or documented infection; a SOFA score increase of =2 points from baseline. Using the CAM-ICU to assess the patient's mental status twice daily, all patients in the ICU are categorized into the SAE group and the non-neurologic septic group based on CAM-ICU results. Patients are placed in the SAE group if they experience acute changes or fluctuations in consciousness, attention deficits, altered levels of consciousness, or confusion

Exclusion criteria

Exclusion criteria: (1) Time in ICU < 24 hours; (2) Age < 18 years; (3) After cardiac and respiratory resuscitation, brain injury, primary central nervous system diseases (stroke, intracranial infection, intracranial mass), metabolic encephalopathy, arrhythmia, intra-aortic balloon pump (IABP), extracorporeal membrane oxygenation (ECMO); (4) Consciousness impairment existed before transferring to ICU; (5) Severe visual or hearing impairment; (6) Chronic kidney dysfunction

Design outcomes

Primary

MeasureTime frame
Septic encephalopathy ;

Countries

China

Contacts

Public ContactTong fei

The second hospital of hebei medical university

26901145@hebmu.edu.cn+86 158 0321 0603

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026