Eczema/dermatitis
Conditions
Interventions
Sponsors
Huzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.On the day of signing the informed consent form, the age range is 18 to 60 years old (including threshold values), and both males and females are eligible; Male weight = 50kg, female weight = 45kg; Body mass index (BMI) = 18 kg/m2 and = 30 kg/m2; 2. Promise not to use cream, moisturizer or other similar products on the back 24 hours before administration until the end of the trial; 3. Promise not to take baths or engage in any strenuous or fatigue inducing activities without authorization during the trial period; 4. Subjects with fertility (male or female) must agree to use a medically approved contraceptive measure during the trial period and within 3 months after the last dose , and have no plans to donate sperm/eggs during the trial period and within 3 months after the end of the trial; 5. Voluntarily participate in this clinical trial, communicate well with the researchers, comply with the requirements of the entire study, and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Any major diseases such as circulatory system, endocrine system, nervous system, digestive system, respiratory system, hematology, immunology, psychiatry, and metabolic abnormalities that the researcher believes may interfere with the trial results or potentially harm the subjects' participation in the trial; 2. Individuals with a history of allergies to drugs, two or more types of food, or other substances, especially to corticosteroids, fluticasone propionate, or any drug excipients used externally or systemically, or who have experienced adverse reactions to corticosteroids used externally or systemically; 3. Currently using medication, especially drugs that act on blood vessels (constrictors or relaxants), prescription or over-the-counter drugs that can regulate blood flow, such as nitroglycerin, antihypertensive drugs, antihistamines, nonsteroidal anti-inflammatory drugs, aspirin, over-the-counter drugs containing antihistamines and/or phenylpropanolamine or phentolamine; 4. Have used topical medications on the back skin or have used topical corticosteroids on any part of the skin within the previous month of screening; 5. Have a history of alcoholism within 6 months before screening, that is, drink more than 14 units of alcohol (1 unit=360 mL beer or 45 mL Baijiu or 150 mL wine with 40% alcohol) every week on average, or the alcohol breath test result is greater than 0.0 mg/100mL; 6. Those who smoke an average of more than 10 cigarettes per day within the first 3 months of screening, or are unable to stop using any form of tobacco during the study period; 7. From 48 hours before the weekly administration to the end of the test, it is impossible to stop eating caffeine, alcohol and other beverages and foods (including chocolate, tea, coffee, cola, etc.), or foods rich in xanthine (such as sardine, animal liver, etc.) or grapefruit, grapefruit products, pitaya, mango, pomelo, orange, carambola, guava and other foods that affect drug metabolism; 8. Individuals with a history of drug abuse (including non-medical use of various types of narcotics and psychotropic drugs) or positive urine drug screening (including morphine, methamphetamine, ketamine, methylenedioxymethamphetamine, tetrahydrocannabinol) within the first 6 months of screening; 9. During screening, vital signs examination, physical examination, clinical laboratory examination (blood routine, urine routine, blood biochemistry, infectious disease screening, coagulation function), and 12 lead electrocardiogram examination show clinically significant abnormalities; 10. Select individuals who have participated in other clinical trials within the previous 3 months; 11. Individuals who have donated blood within the past 3 months, those who have lost 400 mL or more of blood due to blood donation or other reasons within the past 6 months (excluding menstrual bleeding in females), or those who plan to donate blood or blood components during the study period or within 1 week after the end of the study; 12. Screening for individuals who have used any medication within the past 2 weeks (including prescription drugs, over-the-counter drugs, herbal preparations, and prescriptions); 13. Select individuals who have undergone surgery within the previous 6 months that, according to the researcher's assessment, may affect drug absorption, distribution, metabolism, and excretion, or who plan to undergo surgery during the study period; 14. Those who have received the vaccine within the previ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cmax;Tmax;AUC0-t;AUC0-8;?z; | — |
Countries
China
Contacts
Public ContactYang Shuixin
Huzhou Central Hospital
Outcome results
None listed