diarrhoea
Conditions
Interventions
Metformin treatment in the group of patients with insulin resistance and presence of diarrhoea:None
IRPL:Conventional treatment + oral placebo
IRPR:Conventional treatment + oral probiotics
Sponsors
Nanchang Reproductive Hospital (Affiliated Reproductive Hospital of Jiangxi University of Traditional Chinese Medicine)
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Experiment 1: 1. Women of childbearing age who are preparing for pregnancy in our hospital, who meet the diagnostic criteria for insulin resistance, and who are not diabetic. 2. Symptoms such as diarrhoea, increased frequency of stools, and watery stools with or without watery stools after administration of metformin for insulin resistance; 3. Patients without chronic diarrhoea, Crohn's disease, irritable abdominal syndrome and other diseases that can cause diarrhoea. No peptic ulcer, digestive system tumour, etc. after relevant examination; 4. No laxative, oral antibiotics, probiotics and other drugs that may cause changes in intestinal flora within one month. 5. No contraindications to oral metformin and no allergy to metformin and pill related ingredients. 6. Be aware of the treatment process and sign an informed consent form. Experiment 2: 1. Women of childbearing age who are preparing for pregnancy in our hospital, who meet the diagnostic criteria for insulin resistance, and who are not diabetic. 2. Symptoms such as diarrhoea, increased frequency of stools, and watery stools with or without watery stools after administration of metformin for insulin resistance; 3. Patients without chronic diarrhoea, Crohn's disease, irritable abdominal syndrome and other diseases that can cause diarrhoea. No peptic ulcer, digestive system tumour, etc. after relevant examination; 4. No laxative, oral antibiotics, probiotics and other drugs that may cause changes in intestinal flora within one month. 5. No contraindications to oral metformin and no allergy to metformin and pill related ingredients. 6. Be aware of the treatment process and sign an informed consent form.
Exclusion criteria
Exclusion criteria: Experiment 1: 1. There is secondary diarrhoea due to a disease. 2. Those who are undergoing enema treatment. 3. History of treatment with oral antibiotics, antidiarrhoeal and laxative drugs within one month, and are using other drugs that may cause diarrhoea. 4. Have a serious active viral or bacterial infection that is not controlled by treatment. 5. Have any other serious or chronic illness that, in the opinion of the investigator, may interfere with the patient's treatment, follow-up, or evaluation. This includes any uncontrolled clinically significant neurological, psychiatric, immunomodulatory, metabolic, and infectious diseases. 6.A history of thromboembolic disease or a predisposition to thrombosis; 7. Patients who are not suitable for probiotic-assisted therapy after diagnosis and assessment by a clinician. Experiment 2: 1. There is secondary diarrhoea due to a disease; 2. Those who are undergoing enema treatment 3. History of treatment with oral antibiotics, antidiarrhoeal and laxative drugs within one month, and are using other drugs that may cause diarrhoea. 4. Have a serious active viral or bacterial infection that is not controlled by treatment; 5. Have any other serious or chronic illness that, in the opinion of the investigator, may interfere with the patient's treatment, follow-up, or evaluation. This includes any uncontrolled clinically significant neurological, psychiatric, immunomodulatory, metabolic, and infectious diseases; 6. A history of thromboembolic disease or a predisposition to thrombosis; 7. Patients who are not suitable for probiotic-assisted therapy after diagnosis and assessment by a clinician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| faecal microbiota;Hart Diarrhoea Score;HOMA-IR;routine blood test;blood biochemistry; | — |
Countries
China
Contacts
Public ContactWeijun Chen
Department of Reproductive Medicine, Nanchang Reproductive Hospital (Affiliated Reproductive Hospital of Jiangxi University of Traditional Chinese Medicine)
Outcome results
None listed