Postpartum pain and depression
Conditions
Interventions
Control Group:none
Esketamine Group I:none
Esketamine Group II:none
Sponsors
Jiangyin People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1)Age 18-40 years; (2)ASA Class II; (3)Pregnancy over 37 weeks; (4)Requires postoperative analgesic treatment; (5)No severe cardiovascular or cerebrovascular diseases; (6)Able to communicate well with the follow-up personnel; (7)Voluntarily participates in the study and signs the informed consent.
Exclusion criteria
Exclusion criteria: 1) Persons with pregnancy-induced hypertension, thyroid dysfunction, preeclampsia and eclampsia, psychosis, inability to communicate pain response; (2) Abnormal increase in uterine activity, such as tetanic contractions, placental abruption, and umbilical cord prolapse; (3) Patients with contraindications for epidural catheterization such as spinal injury history or deformity; (4) People who are allergic to opioids or have a history of abuse of such drugs (5) Patients at serious risk of elevated blood pressure or intracranial pressure; (6) Patients with poorly controlled or untreated hypertension; (7) severe fetal abnormalities; (8) dangerous placenta previa; (9) Patients with labor analgesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EPDS scores ;nflammatory cytokine (IL-6), neurotransmitter (5-HT), and hormone (PRL) levels before and after 7 and 28 days postpartum; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;Maternal hospitalization days and satisfaction; | — |
Countries
China
Contacts
Public ContactLiu Wanchao
Jiangyin People's Hospital
Outcome results
None listed