Postoperative Cognitive Dysfunction
Conditions
Interventions
EC2:Anesthesia induction begins with continuous infusion of 0.2mg/kg/h ketamine, for 1 hour
EC4:Anesthesia induction begins with continuous infusion of 0.4mg/kg/h ketamine, for 1 hour
control group:none
Sponsors
The Second Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age greater than or equal to 60 years old; 2. American Society of Anesthesiologists (ASA) physical condition grades I-III; 3. Patients who experience discomfort in the lower back due to various reasons and require surgical treatment; 4. Surgical duration = 1.5 hours.
Exclusion criteria
Exclusion criteria: 1. Age under 60 years old 2. Obesity (BMI>40); 3. Abnormal cardiac function; 4. Severe liver and kidney dysfunction or diabetes; 5. Having mental illness, inability to cooperate, taking psychotropic drugs, and difficulty in verbal communication; 6. Severe coagulation dysfunction; 7. History of severe drug allergies; 8. Lost or withdrawn from the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| extubation;Intraoperative Use of Vasoactive Drugs;Hospitalization duration;RASS; | — |
Countries
CHINA
Contacts
Public ContactXu Tongzhang
The Second Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed