ischemic cerebrovascular disease
Conditions
Interventions
Dexmedetomidine Group:Dexmedetomidine was injected by 1.0ug/kg for 10 min before anesthesia induction, and then anesthesia induction was performed. After induction, dexmedetomidine 0.40ug/kg/h was c
Control Group:Routine general anesthesia was performed.
Sponsors
Tianjin Huanhu Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Indications for patients with carotid endarterectomy were determined by angiography:patients with carotid artery stenosis of more than 70% and no symptoms or only mild headache symptoms, the patient with carotid artery stenosis of more than 50% and obvious symptoms; (2) Age:18~70,gender was not limited; (3) ASA classification: II ~ ?, NYHA cardiac function classification: II ~ ?; (4) Written informed consent and assent were obtained from patients.
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications for carotid endarterectomy were precluded beforehand: patients with acute massive cerebral infarction, liver, kidney and lung failure and other organs that cannot undergo surgey, patients with active inflammation on the surgical position; (2) Patients were suffering from Severe neurological dysfunction, cognitive dysfunction or mental illness; (3) Patients had a previous history of carotid artery, surgery or serious trauma or major surgery(within 3 months; (4) Patients had a previous history of hypersensitivity to the anaesthetic drug; (5) MMSE score adjusted for education was below 24 ; (6) Patient or family refused to be involved in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regional cerebral oxygenation;Middle cerebral artery flow velocity;Postoperative cognitive function;Inflammatory index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vasoactive drug dosage in operation;Oxidative stress index; | — |
Countries
China
Contacts
Public ContactJiang Lianhao
Tianjin Huanhu Hospital
Outcome results
None listed