Study on the clinical mechanism of acupuncture in the treatment of ulcerative colitis complicated with depression

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400090379

Enrollment

Unknown

Registered

2024-09-29

Start date

2024-10-31

Completion date

Unknown

Last updated

2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis complicated with depression

Interventions

Ulcerative colitis complicated with depression group:Draw blood

Ulcerative colitis group:Draw blood

Depression group:Draw blood

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) 18 years<=Age<=60 years; (2) Ulcerative colitis group: Meet the diagnostic criteria for ulcerative colitis in the Consensus Opinion on the Diagnosis and Treatment of Inflammatory Bowel Disease, the severity of the disease is mild or moderate, Mayo score = 10; Depression group: Meet mild (8 = 17-item Hamilton Depression Rating Scale score <14) and moderate (14 = 17-item Hamilton Depression Rating Scale score <20); Ulcerative colitis complicated with depression group: Meet the diagnostic criteria for ulcerative colitis in the Consensus Opinion on the Diagnosis and Treatment of Inflammatory Bowel Disease, the severity of the disease is mild or moderate, Mayo score = 10; and Meet mild (8 = 17-item Hamilton Depression Rating Scale score <14) and moderate (14 = 17-item Hamilton Depression Rating Scale score <20); (3) 5-ASA treatment is ineffective and there is no allergic reaction to biologics; (4) Have not been treated with antidepressants within the previous 1 month; (5) Those who have not participated in a clinical study of another drug in the last 3 months; (6) Subjects and their guardians volunteered to participate in this study and signed an informed consent form.

Exclusion criteria

Exclusion criteria: (1) Prior psychiatric history: history of severe suicidal ideation, rigidity, obsessive-compulsive disorder, bulimia, or other severe mental disorder; evidence of alcohol or other substance dependence or abuse; (2) Combined with serious heart, brain and blood vessel diseases and more serious liver and kidney function impairments; (3) Have a malignant tumor; (4) Pregnant or lactating women; (5) Those who cannot adhere to the treatment and follow-up.

Design outcomes

Primary

Measure	Time frame
Plasma cell changes;Exosomal changes in plasma;Molecular changes in plasma aberrantly expressing cells;Indicators of plasma inflammatory factor;	—

Countries

China

Contacts

Public ContactLin Yu

The Affiliated TCM Hospital of Guangzhou Medical University

yul@gzhmu.edu.cn+86 134 3020 0806

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026