Cardiopulmonary interactions
Conditions
Interventions
Driving pressure-guided ventilation strategy group:NA
Traditional protective ventilation strategy group:NA
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older, 2. ASA classification I–III, 3. Expected one-lung ventilation (OLV) duration of =60 minutes, 4. Patients scheduled for elective thoracoscopic lung resection (wedge resection, segmentectomy, single-lobe resection, or bilobectomy)
Exclusion criteria
Exclusion criteria: 1. Contraindications for PEEP (right heart failure, bronchopleural fistula, intracranial hypertension), 2. History of radiotherapy or chemotherapy, 3. History of severe complications (severe heart failure, pulmonary infection, pleural effusion, atelectasis, respiratory failure, pulmonary edema), 4. Severe arrhythmia before surgery, 5. Post-pacemaker implantation, 6. Intraoperative massive bleeding (more than 500 ml), 7. Extrathoracic surgery, 8. Patients who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate variability (HRV);Myocardial injury biomarkers;Acute myocardial infarction within 30 days post-surgery;Arrhythmia within 30 days post-surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| PEEP;Tidal volume;peak pressure;Dynamic lung compliance;Static lung compliance;oxyhemoglobin saturation;ejection fraction;Fractional Shortening;E/A;S/D;stress;Global Longitudinal Strain;Pain intensity score;Quality of recovery score;ICU admission rate;Duration of ICU stay;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactChen Lianhua
Shanghai General Hospital
Outcome results
None listed