Chronic obstructive pulmonary disease
Conditions
Interventions
Pre-COPD subjects:None
None Pre-COPD subjects:None
Sponsors
Zhujiang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Pre-COPD subjects: (1) 18-80 years old; (2) FEV1/FVC = 0.7 after inhaled bronchodilators; (3) fulfillment of any of the following indices: a non-obstructive chronic bronchitis (chronic cough and/or chronic sputum and/or dyspnea of more than 2 consecutive years, with a duration of more than 3 months per year); b imaging suggestive of emphysema and/or large pulmonary blisters (alveoli); c Small airway dysfunction with two or more pulmonary function indices of MEF50, MEF25, and MMEF <65%pred; d low MMEF (<65%pred); e low DLCO (<80%pred); and f prism (FEV1/FVC =0.7, FEV1 <80%pred). Non-Pre-COPD subjects: (1) 18-80 years old; (2) FEV1/FVC =0.7 after inhaled bronchodilators; (3) no manifestations of non-obstructive chronic bronchitis (chronic cough and/or chronic sputum and/or dyspnea of more than 2 consecutive years, lasting more than 3 months per year; (4) no manifestations of emphysema and/or pulmonary pustules (large alveoli) on imaging; (5) pulmonary function without manifestations of small airway dysfunction (MEF50, MEF25, two or more MMEF <65%pred), low MMEF (<65%pred), low DLCO (<80%pred), prism (FEV1/FVC =0.7, FEV1 <80%pred).
Exclusion criteria
Exclusion criteria: (1) previous definitive diagnosis of COPD; (2) history of comorbid chronic respiratory diseases such as asthma, gastroesophageal reflux disease, postnasal drip syndrome, pharmacogenic cough, tracheo-bronchial tuberculosis, bronchiectasis, bronchopulmonary carcinoma, pneumothorax, pleural effusion, thoracic deformity, chronic pharyngitis, history of severe cardiac, hepatic, and renal diseases, or history of malignant tumors with a definitive diagnosis of COPD; (3) previous history of lung resection surgery ; (4) pregnant and lactating women; (5) incomplete baseline and follow-up data and other conditions judged by the investigator to be unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ratio of the Forced Expiratory Volume in one second to Forced Vital Capacity; | — |
Secondary
| Measure | Time frame |
|---|---|
| FVC/pred;FEV1/pred;MEF75/pred;MEF50/pred;MEF25/pred;MMEF/Pred;DLCO%pred; | — |
Countries
China
Contacts
Public ContactChen Xin
Zhujiang Hospital, Southern Medical University
Outcome results
None listed