Bacterial infection in adults
Conditions
Interventions
Piperacillin sodium tazobactam sodium group:None
Ceftazidime and avibactam sodium group:None
Sponsors
Xi'an Honghui Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Admission diagnosis was complex intraperitoneal infection, community-acquired pneumonia, hospital-acquired pneumonia, Patients with ventilator-associated pneumonia and urinary tract infections; 2. Ages 18 to 85 (including 18 and 85), gender unspecified; 3. After qualified sampling, and positive bacterial culture; 4. Piperacillin sodium and tazobactam sodium or ceftazidime and avibactam sodium were used to treat bacterial infection; 5. Complete and complete case data; 6. Patients or their families give informed consent to this protocol.
Exclusion criteria
Exclusion criteria: 1. Patients with long-term systemic history of glucocorticoid administration and immune dysfunction; 2. Allergic to piperacillin sodium tazobactam sodium or ceftazidime and avibactam sodium; 3. Patients with liver, kidney, heart and other vital organ failure; 4. Medication can not complete the corresponding course of treatment, less than 3d, and does not cooperate with relevant examination, treatment or baseline information Harvester; 5. The investigator considers that there are other conditions that are not suitable for participation in clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessing the difference in treatment efficacy between two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessing the difference in bacterial clearance rates between two groups;Evaluate the difference in inflammatory markers, including procalcitonin, C-reactive protein, and white blood cell count, between the two groups of patients.;Assess the distribution of pathogens, pathogen culture results, and drug resistance status in the two groups of patients.;Evaluate the difference in average length of stay and pharmaceutical economics between the two groups of patients.;The incidence of adverse reactions associated with therapeutic medications.; | — |
Countries
China
Contacts
Public ContactZhang Binfei
Xi'an Honghui Hospital of Xi'an Jiaotong University
Outcome results
None listed