Pain
Conditions
Interventions
Sufentanil group (S group):Sufentanil (0.15 µg/kg) combined with propofol (1.5 mg/kg)
Sponsors
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing sedated hysteroscopic surgeries; 2. 18-65 years old; 3.American Society of Anesthesiologists (ASA) Physical Status I–II; 4. Estimated surgical time within 30 minutes; 5. Written informed consent and voluntary participation in this study.
Exclusion criteria
Exclusion criteria: 1. Body mass index (BMI) > 35 kg/m^2 or weight > 75 kg; 2. Patients diagnosed with obstractive sleep apnea; 3. Patients with a history of opioid allergy and contraindication; 4. Long-term use of opioids (defined as >15 morphine equivalent units per day for more than 3 days per week, duration more than 1 month within 1 year before the surgery); Use of any analgesic drug within it's 5 half-life periods (or 48 hours, if unknown) before surgery; Long-term use of non-steroidal anti-inflammatory drugs (daily use for more 2 weeks in the 6 months before surgery, except aspirin =30 days; 6. Severe respiratory insufficiency; 7. Patients with subclinical respiratory depression before surgery; 8. Abnormal electrocardiogram result (QTcF interval > 470 ms at screening time), or abnormal liver or kidney function; 9. Inability to cooperate with the study for any reason, such as: language understanding, mental illness, inability to visit the research center, etc; 10. The investigator considers it inappropriate for inclusion in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypoxia in sedated hysteroscopy (75% <=SpO2 < 90%, <60 s); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of subclinical respiratory depression in sedated hysteroscopy (90%60 s);Blood pressure and heart rate 5 minutes after induction of anesthesia;Patient's body movement times and propofol supplemental dose during hysteroscopy;Pain score in the PACU immediately after surgery;Whether hypoxia, subclinical respiratory depression, and severe hypoxia occurred in the PACU;Arterial blood gas analysis in the PACU;The incidences of nausea and vomiting were observed in the PACU;Patient satisfaction with anesthesia experience;surgeon satisfaction with anesthesia experience;Whether airway opening is used; | — |
Countries
China
Contacts
Public ContactSong Zhang
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed