Efficacy of Intra-Articular Injection of Platelet-Rich Plasma Combined with Hyaluronic Acid in the Treatment of Knee Osteoarthritis

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400090332

Enrollment

Unknown

Registered

2024-09-27

Start date

2023-01-05

Completion date

Unknown

Last updated

2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee

Interventions

PRP+HA Group:Intra-articular injection of PRP and HA combination once weekly for three weeks.

PRP Group:Intra-articular injection of autologous PRP once weekly for three weeks.

HA Group: Intra-articular injection of HA once weekly for three weeks.

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Diagnosis of knee osteoarthritis according to the criteria of the American College of Rheumatology (ACR); Kellgren-Lawrence grade II-III.; Age between 40 and 70 years.; Voluntary participation and signed informed consent.

Exclusion criteria

Exclusion criteria: Severe cardiovascular, cerebrovascular, hepatic, or renal diseases; Contraindications for intra-articular injections, such as joint infection or skin lesions;Received intra-articular injection therapy within the last three months; Allergic to the treatment medications; Poor compliance or inability to complete follow-up.

Design outcomes

Primary

Measure	Time frame
Visual Analog Scale, VAS;	—

Secondary

Measure	Time frame
Western Ontario and McMaster University Osteoarthritis Index, WOMAC;range of motion, ROM;	—

Countries

China

Contacts

Public ContactChen Bingcan

Pingdingshan First People's Hospital

13393796757@163.com+86 133 9379 6757

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026