protrusion of lumbar intervertebral disc
Conditions
Interventions
Lumbar endoscopic treatment group (A Group):only endoscopic treatment
Lumbar endoscopic treatment + Annulus suture group (B Group):endoscopic treatment + Annulus suture
Lumbar endoscopic treatment + Injection of stromal vascular fraction + Annulus suture group:endoscopic treatment + Injection of stromal vascular fraction +Annulus suture
Sponsors
The Second Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Age > 18 years and < 80 years; ? Non-pregnant and lactating women; ? The patient is suffering from protrusion of lumbar intervertebral disc (refers to the clinical syndrome caused by lumbar disc degeneration, partial or total rupture of the annulus fibrosus, nucleus pulposus protrusion stimulation or compression of nerve roots and cauda equina nerve, radiating pain of lower extremities, numbness of lower extremities, and even urinary and bowel dysfunction); ?The imaging examination of the lumbar spine (CT, MRI) diagnosed single-level lumbar protrusion, protruding disc compression of nerve tissue (nerve root or spinal cord); ?Have obvious clinical symptoms of protrusion of lumbar intervertebral disc, including low back pain, lower limb numbness pain; The physical examination patients showed positive signs of straight leg elevation test and strengthening test, positive femoral nerve pulling test, and positive spinal spinous process tenderness and tapping pain. ?More than 2 weeks of conservative treatment, no significant improvement in symptoms, seriously affecting the quality of life of patients; ?The patient had a strong desire to undergo surgery, and fully understood the differences in biological products used in the clinical study and the complications of lumbar endoscopy surgery and fibrous suture, and signed informed consent to voluntarily join the clinical trial.
Exclusion criteria
Exclusion criteria: ? Patients with serious primary diseases such as cardiovascular, liver, kidney and hematopoietic system, mental patients and malignant diseases such as tumors; ? Combined with congenital lumbar deformity, previous infection history, tumor history, trauma history, etc., resulting in significant abnormal changes in lumbar morphology; ?Patients with lumbar instability or lumbar spondylolisthesis, lumbar fracture, tuberculosis or tumor; ? Patients who have previously undergone spinal surgery; ?Compression diseases in other parts of the spine other than the lumbar spine, such as cervical disc degeneration, cervical hyperextension, cervical posterior longitudinal ligament ossification, thoracic posterior longitudinal ligament ossification, thoracic ligamentum yellow ossification, etc.; ?There are other diseases such as piriformis syndrome, sciatic nerve injury, poliomyelitis, Guillain-Barre syndrome that affect nerve function and thus interfere with postoperative efficacy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative recurrence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;ODI; | — |
Countries
China
Contacts
Public ContactChengzhen Liang
Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed