Postoperative pain
Conditions
Interventions
Experimental group:Esketamine+Sufentanil
Control group:Sufentanil
Sponsors
Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients who are scheduled for laparoscopic gastrointestinal surgery and are aged =60 years, with surgical types including laparoscopic gastrectomy, colectomy, and rectectomy for gastric, colon, and rectal cancer, respectively; 2.American Society of Anesthesiologists (ASA) classification I to III; 3. Consent to postoperative intravenous patient-controlled analgesia; 4. Body Mass Index (BMI) between 18 and 30 kg/m²; 5. Willingness to participate in the study and signing of an informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of chronic pain; 2. History of opioid or alcohol abuse; 3. Significant cognitive impairment already present before surgery; 4. Neurological disorders; 5. Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure exceeding 180/100 mmHg); 6. Elevated intraocular pressure (glaucoma) or increased intracranial pressure; 7. Patients with untreated or inadequately treated hyperthyroidism; 8. Severe cardiopulmonary,liver and kidney dysfunction; 9. Severe visual impairment; 10. Lack of cooperation or communication ability; 11. Allergy to the active ingredients or excipients of the study medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The consumption of opioid drugs at 24h and 48h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative quality of recovery ;Patient controlled intravenous analgesia (PCIA) press number;Resting and cough pain scores;Time to first postoperative gas and bowel movement;Incidence of delirium 3 days after surgery;Athens Insomnia Scale;Anesthesia-related complications;Intraoperative consumption of remifentanil; | — |
Countries
China
Contacts
Public ContactJiang Peng
Affiliated Hospital of Jiangsu University
Outcome results
None listed