Heart Failure with Preserved Ejection Fraction
Conditions
Interventions
Control Group:Standard Western medical treatment will be administered for 12 weeks, followed by observation of therapeutic efficacy after 12 weeks
Experimental Group:On the basis of standard Western medical treatment, the experimental group will receive the core prescription Yixin Jiedu Formula (compound: Astragalus granules 30g, Salvia miltiorr
all Chinese herbs are uniformly prepared, one dose daily, orally/nasogastrically), administered for 12 weeks, with efficacy observed after 12 weeks.
Sponsors
Guangdong Provincial Hospital of Chinese Medicine (Main Hospital ICU)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients with Heart Failure with Preserved Ejection Fraction: ?Meet the diagnostic criteria for heart failure with preserved ejection fraction. ?Meet the diagnostic criteria for Qi deficiency and blood stasis syndrome in traditional Chinese medicine for heart failure. ?Age between 18 and 80 years old, any gender. ?Patients who have signed an informed consent form and are willing to undergo relevant examinations and treatments.
Exclusion criteria
Exclusion criteria: ?Patients with obstructive heart disease, constrictive pericarditis, cardiac tamponade, valvular heart disease, pulmonary embolism, severe and uncontrolled arrhythmias, or heart failure combined with uncontrolled infections; ?Patients with severe primary diseases of other internal medical systems such as liver, kidney, blood, and endocrine systems; ?Patients with mental disorders who cannot cooperate properly to complete the study; ?Pregnant and lactating women; ?Patients allergic to medications in this study protocol or specific components thereof; ?Patients unable to take medications as prescribed, affecting the assessment of efficacy, or patients with incomplete clinical data that cannot accurately assess the efficacy of drug treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-proBNP change rate from baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular death, heart failure readmission rate, or composite endpoint of emergency visits due to heart failure;Cardiac ultrasound: LVEF, E/E', LVMI, LVM, LAV, LAVI, LVDd, LVDs, E/A, TRV;6-minute walk test;KCCQ score;Traditional Chinese medicine syndrome score;Incidence rate of adverse events; | — |
Countries
China
Contacts
Public ContactMaoshuai
The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed