The Effect of Mindfulness-Based Cognitive Therapy for Generalized Anxiety Disorder and its Physiological-Psychological Regulatory Mechanisms

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400090284

Enrollment

Unknown

Registered

2024-09-26

Start date

2024-10-01

Completion date

Unknown

Last updated

2024-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized Anxiety Disorder

Interventions

MBCT group:Alongside SSRI medication treatment, an adjusted 8-week Mindfulness-Based Cognitive Therapy (MBCT) program developed by Segal and others is added, tailored to the characteristics of patient

Control group:Treatment as usual (Both groups received drug treatment, with the main treatment drug used being a single SSRI drug, with limited use of benzodiazepine sedatives and hypnotics, and non-b

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) meets the diagnostic criteria for Generalized Anxiety Disorder (GAD) according to the International Classification of Diseases, 10th Revision (ICD-10), diagnosed by two or more psychiatrists; (2) aged 18-60 years, no gender limitation; right-handed; (3) educational level of junior high school or higher, capable of cooperating with questionnaire assessments and psychotherapy; (4) score =17 on the Hamilton Anxiety Rating Scale; (5) both patient and their dependents agree to participate in the study.

Exclusion criteria

Exclusion criteria: (1) Those with a history of cerebral organic diseases and other neurological diseases, physical diseases, use of psychoactive substances or drug dependence; (2) Have used thyroid preparations, immunomodulators, cortisol hormones, lithium salts, etc. within the past six months; (3) Combined with schizophrenia, schizoaffective disorder, depression, and bipolar disorder; (4) Patients with severe suicidal tendencies; (5) Those who have received mindfulness intervention in the past two years; (6) Absence from treatment for more than 3 times during the study period; (7) Pregnancy or lactation.

Design outcomes

Primary

Measure	Time frame
Hamilton Anxiety Rating Scale;	—

Secondary

Measure	Time frame
Hamilton Depression Rating Scale;Self-Rating Anxiety Scale;Self-Rating Depression Scale;Clinical Global Impression ;The Short-Form 36;Self-Esteem Scale;Simplified Coping Style Questionnaire ;Defence Style Questionnaire ;Global Assessment Function;Five Facet Mindfulness Questionnaire ;Pittsburgh Sleep Quality Index;MATRICS Consensus Cognitive Battery;Stroop Colour-Word Test;N-back task;Cortisol levels;Hypothalamic-Pituitary-Thyroid (HPT) axis function: thyroid hormones;	—

Measure

Time frame

Hamilton Depression Rating Scale;Self-Rating Anxiety Scale;Self-Rating Depression Scale;Clinical Global Impression ;The Short-Form 36;Self-Esteem Scale;Simplified Coping Style Questionnaire ;Defence Style Questionnaire ;Global Assessment Function;Five Facet Mindfulness Questionnaire ;Pittsburgh Sleep Quality Index;MATRICS Consensus Cognitive Battery;Stroop Colour-Word Test;N-back task;Cortisol levels;Hypothalamic-Pituitary-Thyroid (HPT) axis function: thyroid hormones;

—

Countries

China

Contacts

Public ContactLei Sun

Tianjin Anding Hospital (Tianjin Mental Health Center)

adsunlei@126.com+86 139 2033 8557

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 26, 2026