pancreatic cancer
Conditions
Interventions
chemotherapy alone group:Chemotherapy was performed using mFOLFIRINOX regimen
Ultrasound treatment + chemotherapy group:Chemotherapy with mFOLFIRINOX regimen combined with ultrasound therapy
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Unresectable with or without distant metastasis confirmed by pathology or cytology (stage IV) of patients with pancreatic cancer, regardless of the number of metastases; 2. Age 18-75 years old, male or female; 3. Imaging assessment (ultrasound, CT or MRI) showed measurable and evaluable tumor lesions; 4. ECOG score 0-1, estimated survival period of more than 3 months; 5. No obvious abnormalities in liver and kidney function: ALT, AST= 2.5 times the upper limit of normal values, Urea, Cr= above normal values The limit is 1.25 times, and ALT and AST in patients with liver metastasis are = 5 times the upper limit of normal; 6.WBC=3.5 ×10^9/L,PLT=80 ×10^9/L,Hb=90 g/L; 7. No history of other malignant tumors; 8. Women of childbearing age must undergo a pregnancy test within 7 days before enrollment; 9. The patient signed the informed consent form agreeing to participate in the trial, was able to be followed up, and compliance was good.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation; 2. Allergy and hypersensitivity to chemotherapeutic drugs; 3. Suffering from severe cardiopulmonary dysfunction; 4. Intestinal obstruction or incomplete ileus; 5. Accompanied by a large amount of ascites; 6. Accompanied by brain and bone metastases; 7. Are receiving treatment with other antitumor drugs or radiotherapy; 8. Participating in other clinical trials at the same time or completing chemotherapy within 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression-free survival;duration of response;objective response rate;disease control rate; | — |
Countries
China
Contacts
Public ContactLi Kai
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed