Clinical study of diluted nitrous oxide on sedation and analgesia in patients with dental scaling

Clinical study of diluted nitrous oxide on sedation and analgesia in patients with dental scaling: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400090261

Enrollment

Unknown

Registered

2024-09-26

Start date

2024-10-01

Completion date

Unknown

Last updated

2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Nitrous oxide group:Inhale nitrous oxide / oxygen mixture

Placebo group:Inhale oxygen

Eligibility

Sex/Gender

All

Age

15 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with stage I to IV periodontitis; Gingivitis patients; patients with degree 2 and 3 dentin hypersensitivity; patients with severe pre-cleaning nervousness and dental anxiety (VAS-A>5) ; American Society of Anaesthesiologists(ASA) anaesthesia risk assessment class I - II

Exclusion criteria

Exclusion criteria: otitis media, sinusitis, bowel obstruction; acute upper respiratory tract infection or other causes of dyspnea; VitB12 deficiency; substance abuse, alcoholism, severe mental illness or abnormality; claustrophobia or nasal mask intolerance; COPD, pneumothorax, and alveolar lungs; methylenetetrahydrofolate reductase deficiency; patients with severe sleep apnoea syndrome.

Design outcomes

Primary

Measure	Time frame
Pain score;anxiety score;	—

Secondary

Measure	Time frame
Physiological parameters;Satisfaction;	—

Countries

China

Contacts

Public ContactLu Tang

25 Shifan Road, Tianqiao District, Ji'nan, Shandong

tanglu_office@163.com+86 150 6400 3655

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026