Hypotension after general anesthesia.
Conditions
Interventions
Part 1: Corrected left ventricular-ejection time prediction for elderly patients with hypotension after induction of general anesthesia group:Corrected left ventricular-ejection time
Part 2: Corrected left ventricular-ejection time guided perioperative fluid therapy group:Corrected left ventricular-ejection time guided perioperative fluid therapy
Part 2: Routine perioperative fluid therapy group:Routine perioperative fluid therapy
Sponsors
Beijing Chao-Yang Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age ranges from 60-85 years old. 2.Scheduled for elective non-cardiac surgery. 3.ASA (American Society of Anesthesiologists) grade I-III classification. 4.Undergoing general anesthesia with endotracheal intubation or/and laryngeal mask airway insertion. 5.Willingness to participate in this study and providing the informed consent.
Exclusion criteria
Exclusion criteria: 1.Poor impedance cardiogram (ICG) waveform caused by obvious interference (such as agitation, coughing, shivering, limb shaking). 2.Poorly controlled hypertension (mean arterial pressure > 130mmHg or systolic blood pressure> 180 or diastolic blood pressure> 110 mmHg for noninvasive or invasive blood pressure after 5 minutes of rest in the preoperative waiting area or in the operation room. 3.Skin rashes, infections, or ulcers at the site where the electrodes of the chest impedance monitoring device to be attached. 4.Severe aortic insufficiency. 5.Atrial septal defect or ventricular septal defect. 6.Severe aortic sclerosis or post-aortic repair surgery. 7.Aortic aneurysm or aortic dissection. 8.Status post-pacemaker implantation. 9.Height below 120cm or above 230cm. 10.Weight less than 30kg or more than 155kg. 11.BMI greater than 30 kg/m2 or less than 15 kg/m2. 12.History of allergies or other serious adverse reactions to the drugs used in the study. 13.History of allergies to medical tape, electrocardiogram electrodes, and medical skin surface dressings involved in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part 1: The area under the ROC curve and optimal threshold of corrected left ventricular-ejection time for predicting hypotension after general anesthesia induction in elderly patients;Part 2: Incidence of hypotension after general anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Part 1: Incidence of hypotension after general anesthesia induction;Part 1: Patient satisfaction 24 hours after surgery;Part 1: Incidence of skin allergy with electrode of non-invasive hemodynamic detector;Part 2: Hemodynamic changes before and after fluid therapy and induction;Part 2: Patient satisfaction 24 hours after surgery;Part 2: Incidence of skin allergy with electrode of non-invasive hemodynamic detector; | — |
Countries
China
Contacts
Public ContactAnshi Wu
Beijing Chao-Yang Hospital, Capital Medical University
Outcome results
None listed