Postoperative cognitive dysfunction
Conditions
Interventions
Esketamine group:The esketamine group was induced with 0.5mg/kg esketamine and then pumped at 2ug/kg.min until half an hour before the end of surgery.
Placebo group :The placebo group was given equal dose of normal saline at the same time point.
Sponsors
Yancheng Third People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age 65-90. 2.ASA grade I-III. 3. Diagnosis of lung, esophageal, or mediastinal disease. 4. Undergo thoracoscopic surgery, including lobectomy, segmental resection, pulmonary resection, esophagectomy, or mediastinal tumor resection. 5. Single lung ventilation (OLV) under general anesthesia 6. The expected duration of surgery is 2 hours or more. 7. Voluntarily participate in the trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative cognitive impairment. 2. Patients with a history of long-term use of drugs that affect neuropsychiatric function (hypnotics, anti-anxiety drugs, and antidepressants). 3. Patients with a history of neurological, psychiatric and cardiovascular diseases (such as Alzheimer's disease, cerebral infarction, coronary artery disease, etc.). 4. Patients with severe visual or hearing impairment who cannot be tested for neurocognitive function. 5. Patients with severe liver or kidney damage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental state examination(MMSE) score;NfL; | — |
Secondary
| Measure | Time frame |
|---|---|
| GFAP;IL-6;TNF-a;Mean arterial pressure (MAP) before anesthesia induction (T0), at the beginning of anesthesia (T1), 30 min after anesthesia (T2), and at the end of surgery (T3);Heart rate before anesthesia induction (T0), at the beginning of anesthesia (T1), 30 minutes after anesthesia (T2), and at the end of surgery (T3);Intraoperative opioid consumption;Length of stay in the anesthesia Care Unit (PACU);24h postoperative pain score (VAS);Adverse reactions (vomiting, dizziness, high blood pressure and tachycardia, hallucinations or nightmares);Whether remedial analgesia occurs; | — |
Countries
China
Contacts
Public ContactYuanyuan Gao
Yancheng Third People's Hospital
Outcome results
None listed