Chronic sinusitis
Conditions
Interventions
Sponsors
General Hospital of Southern Theater Command of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Age range: 18-60 years old; 2) Meets the standards for endoscopic sinus surgery; 3) The patient voluntarily participates in this study and signs a written informed consent form, willing to cooperate with follow-up.
Exclusion criteria
Exclusion criteria: 1) Combined hypertension; Diabetes; Patients with a history of taking sedatives for hyperlipidemia; 2) Carotid artery stenosis; Patients with a history of ischemic attacks or cerebral infarction; 3) Patients with a history of taking anticoagulant drugs; 4) When screening for examination, the patient's alanine aminotransferase (ALT) or aspartate aminotransferase (AST) is greater than or equal to 1.5 times the upper limit of the normal value specified by the center, or the endogenous creatinine clearance rate (CCr) is greater than the upper limit of the normal value specified by the center; 5) When screening, the total white blood cell count (WBC) in the patient's blood routine is greater than 10.0X109/L or less than 1.0X09/L; 6) History of any illness that may affect adherence to the protocol (such as severe mental disorders, cognitive impairment, drug abuse or addiction, etc.); 7) Pregnant or lactating women, or those who have the ability to conceive and are unwilling/unable to take effective contraceptive measures; 8) Individuals who are known to be allergic to the ingredients contained in the medication used in this study; 9) Individuals who have participated in any drug clinical trials within the past 6 months prior to screening and examination; 10) Researchers determine that patients who are not suitable to participate in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of rSO2 after target controlled infusion of dexmedetomidine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in heart rate after target controlled infusion of dexmedetomidine;Changes in blood pressure after target controlled infusion of dexmedetomidine;Surgical field clarity score;Intraoperative blood loss;PACU residence time;Incidence of postoperative nausea and vomiting;Use of analgesic drugs 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactHuan He
General Hospital of Southern Theater Command of PLA
Outcome results
None listed