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The effect of different courses of prophylaxis against infection on maternal and infant outcomes in pregnant women with PPROM

The effect of different courses of prophylaxis against infection on maternal and infant outcomes in pregnant women with PPROM

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400090171
Enrollment
Unknown
Registered
2024-09-25
Start date
2024-10-08
Completion date
Unknown
Last updated
2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PPROM

Interventions

Treatment <7d group:none
Treatment =7d group:none

Sponsors

the First Affiliated Hospital of Army Medical University, PLA
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: (1) Cases with a ruptured gestational week of 24-33+6 cycles to be preserved; (2) The drug regimen for infection prevention was penicillin G 4MIU q12h for patients who were not allergic to ß-lactams, first-generation cephalosporins (cefazolin 2g q12h, cefathiamidine 2g q12h) to prevent infections, and clindamycin 0.6g q12h for patients allergic to ß-lactams. (3) The pregnancy was eventually terminated in our hospital.

Exclusion criteria

Exclusion criteria: (1) Combination of serious pregnancy complications or complications that endanger the life of the mother and child, e.g., severe preeclampsia, liver disease, and severe anemia; (2) Admission has been clearly diagnosed with infection; (3) The patient has undergone multiple (>1) prophylaxis for infection due to PPROM.

Design outcomes

Primary

MeasureTime frame
Adverse maternal and infant outcomes;

Countries

China

Contacts

Public ContactZheng Mingyu

the First Affiliated Hospital of Army Medical University, PLA

zheng1111@tmmu.edu.cn+86 134 3618 5498

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026