postoperative analgesia
Conditions
Interventions
Experimental group:Acetaminophen mannitol injection 500mg/6h, PCIA sufentanil after surgery
control group:PCIA sufentanil within 48 hours after surgery
Sponsors
Qingdao Municipal Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: Age range from 45 to 75 years old; Both male and female; Able to understand the research process and communicate effectively with researchers, able to cooperate with relevant scale assessments and respiratory function testers; Non allergic constitution, and not allergic to the drugs specified in this study protocol; No previous history of open heart and chest surgery; No history of chronic pain disease or moderate or above valve disease or endocarditis; Body mass index (BMI) 18 = BMI = 30, and body weight>50kg; The patient agrees to participate in clinical research and signs an informed consent form.
Exclusion criteria
Exclusion criteria: IABP or ECMO assisted circulation is required before surgery; Severe arrhythmia; Preoperative left ventricular ejection fraction<30%; Having a history of respiratory infection or chronic obstructive pulmonary disease or bronchial asthma in the past month requires regular treatment; Viral hepatitis, active liver disease, abnormal liver function; Renal dysfunction or dialysis 28 days before surgery; Use acetaminophen within 12 hours before surgery or other analgesics within 24 hours; Participated in other clinical trials within 4 weeks before surgery; Other situations that the researchers believe are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory Function;Analgesia situation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inspection indicators;Postoperative adverse reactions;postoperative vital signs; | — |
Countries
China
Contacts
Public ContactLixin Sun
Qingdao Municipal Hospital
Outcome results
None listed