Neuropathic Pain
Conditions
Interventions
Targed taVNS group:Following cleaning of the conchal skin with alcohol pads, electrodes will be placed on the concha of the ear. For the targeted taVNS group, the amplitude will increase within 30s un
Non-targeted taVNS group:Following cleaning of the conchal skin with alcohol pads, electrodes will be placed on the concha of the ear. For non-targeted taVNS group, the amplitude adjusted as above. In
sham stimulation group:Following cleaning of the conchal skin with alcohol pads, electrodes will be placed on the concha of the ear. For the sham taVNS groups, the amplitude will also increasing withi
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1)Male or female patients aged over 18 and under 75 years. 2)Pain for at least 3 months, continuous pain (at least 4 day per week), at least moderate tensity [=4/10 on a 0-10 numerical rating scale for pain (NRS) on average on the Brief Pain Inventory (BPI)]. 3)Pain fulfilling the criteria for probable or definite peripheral neuropathic pain (A.the area of pain corresponds to the anatomical distribution of peripheral sensory nerves; B. history suggestive of asscociated damage or disease of the pNP; C. Neurological examination confirms the presence of at least 1 sign in the area of pain distribution associated with nerve damage or disease; D.at least 1 auxiliary examination confirms the presence of relevant impairment or disease of the somatosensory system. Simultaneous compliance with A to D is a confirmed diagnosis, and compliance with A to C or ABD is a probable diagnosis.) and scoring 4/10 on the DN4 questionnaire (trigeminal neuralgia does not require to completion of DN4 questionnaire). 4)Stable phamacological treatment for pain at least 4 weeks or never took relevant treatment. 5)With informed consent
Exclusion criteria
Exclusion criteria: 1)Other type of pain more severe than neuropathic pain. 2)Evidence of severe systemic disease. 3)Other conditions that cause cognitive dysfunction and mental abnormalities including dementia, affective disorders, and schizophrenia. 4)History of substance abuse (alcohol, drugs). 5)Epilepsy. 6)Implanted ferromagnetic devices, e.g. cardiac pacemaker, cochlear implants, intracranial vascular stents. 7)Pregnancy or breastfeeding. 8)Undergoing other neurological stimulation. 9)Participation in another research protocal within 1 month before inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 0-10 numerical rating scale; | — |
Countries
China
Contacts
Public ContactSongjie Liao
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed