Postoperative neurocognitive disorders
Conditions
Interventions
Control group:No intervention
Prophylactic norepinephrine Infusion group(N group):Noradrenaline was infused immediately after aspinal anesthesia at a rate of 0.01 ug / kg/min, adjusted within the range of 0-0.1ug/kg/min, and blood
Sponsors
Jiangsu Subei People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) ASA grade I-III; (2) Patients with indications for hip replacement surgery; (3) Age=65 years old, with no limit on gender; (4) Body mass index (BMI) of 18-24 kg/m^2; (5) Normal communication can be conducted (6)Hypertension I-II
Exclusion criteria
Exclusion criteria: (1) Simple Mental State Scale (MMSE) score: =180mmHg and/or DBP>=110mmHg) and secondary hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of POD;Incidence of neurocognitive disorders within 90 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of hypotension;Hospital complications (including reactive hypertension, bradycardia, nausea and vomiting,);Complications within 90 days (cardiovascular and cerebrovascular accidents, renal impairment, etc.);postoperative fatigue syndrome;Postoperative pain;Length of hospitalization;rS02 ;The Tau protein; | — |
Countries
China
Contacts
Public ContactYali Ge
Jiangsu Subei People's Hospital
Outcome results
None listed