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Biological measurement of upper eyelid structure in patients with aponeurotic ptosis by 22Hz high-frequency ultrasound

Biological measurement of upper eyelid structure in patients with aponeurotic ptosis by 22Hz high-frequency ultrasound

Status
Active, not recruiting
Phases
Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400090094
Enrollment
Unknown
Registered
2024-09-24
Start date
2024-10-01
Completion date
Unknown
Last updated
2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aponeurotic ptosis

Interventions

Data collection:Ultrasonic image acquisition and measurement of upper eyelid tissue
Case control group:Ptosis parameter measurement, Ultrasonic image acquisition and measurement of upper eyelid tissue
Auto-control group:Ptosis parameter measurement, Ultrasonic image acquisition and measurement of upper eyelid tissue

Sponsors

Eye Hospital of Wenzhou Medical University at Hangzhou
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Patients aged 20-60 years old were clinically diagnosed as uniocular or binocular aponeurotic ptosis. Diagnostic criteria for ptosis: under the action of excluding the frontal muscle, the upper palpebral margin covered the upper corneal margin > 2mm when the eyes were opened at the same level. (2) Patients aged between 20 and 60 years old were clinically diagnosed with monocular aponeurotic ptosis. Diagnostic criteria for ptosis: under the action of excluding the frontal muscle, the upper palpebral margin covered the upper corneal margin > 2mm when the eyes were opened at the same level. (3) Muscle strength of eyelid levator in both eyes was > 8mm. (4) The characteristic clinical manifestations of the affected eye with partial aponeurotic ptosis are: double eyelids become wider and shinier or disappear, the upper sulcate depression is deepened, the eyebrows are raised, the eyelids become thinner, and the eyelids become more downward when looking down. (5) Patients aged 20-60 years with clinically diagnosed ptosis without the characteristic clinical manifestations of aponeurotic ptosis. Outpatient patients who meet the above three criteria (1, 3, and 4) are the case group, and those who meet (5) are the healthy control group, and will be invited to participate in the case-control study of this study. Outpatient patients who meet the above criteria (2, 3, and 4) will be invited to participate in the self-controlled study of this study.

Exclusion criteria

Exclusion criteria: Exclusion criteria were previous eyelid or orbital surgery or trauma, strabismus, superior rectus muscle palsy or facial palsy, oculomotor nerve palsy, Horner syndrome, Marcus Gunn syndrome, upper eyelid laxation covering more than the upper eyelid edge, other related eyelid diseases, neurogenic, myogenic, mechanical, pseudoptosis, myasthenia gravis, or other myopathies.

Design outcomes

Primary

MeasureTime frame
The thickness of the upper eyelid aponeurosis measured by ultrasound ;Upper eyelid thickness ;

Secondary

MeasureTime frame
Thickness of skin and subcutaneous tissue layer;Orbicularis oculi muscle thickness;Tarsus thickness and width;The distance between the orbital septa-levator aponeurosis fusion and superior margin of superior tarsus;Morphology of aponeurosis of levator eyelid;Levator palpebral muscle strength ;Palpebral fissure height at head-up ;Lower eyelid retraction value at eye level ;Eyelid appearance morphology ;

Countries

China

Contacts

Public ContactHaochen Guo

Eye Hospital of Wenzhou Medical University

haochenguo3275@163.com+86 137 7757 0553

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026