Metabolic associated fatty liver disease
Conditions
Interventions
Gold Standard:MR Proton Density Fat Fraction (MR-PDFF)
Index test:USAT, Ultrasonic Attenuation, HepatoRenal Index (HRI) based on the original data of acoustic attenuation imaging, LTI, Texture Index based on acoustic attenuation imaging, and BMI, waist ci
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: ? Chinese citizens aged = 18 and = 60. ? Meets MAFLD diagnostic criteria: In adults with hepatic steatosis (detected either by imaging techniques, blood biomarkers/scores, or liver histology), these three groups are classified as MAFLD, namely overweight/obesity (BMI = 23 kg/m2), type 2 diabetes (T2DM) or metabolic disorder. The presence of at least two of the following metabolic risk abnormalities: • Waist circumference =90/80 cm in men and women • Blood pressure =130/85 mmHg or specific drug treatment • Plasma triglycerides =150 mg/dL (=1.70 mmol/L) or specific drug treatment • Plasma HDL-cholesterol 2 mg/L ? The patient agrees and voluntarily joins this study and signs an informed consent form. ? The patient has completed MR-PDFF examination according to clinical needs, and the examination is within 1 week of enrollment time.
Exclusion criteria
Exclusion criteria: ? Pregnant. ? Patients undergoing systemic chemotherapy or biological therapy, or patients after TACE surgery; Patients with tumors in the liver lobe segments to be sampled. ? The course of diabetes patients is more than 2 years or has a history of kidney disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasound Attenuation;Area under ROC curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| HepatoRenal Index;Texture Index; | — |
Countries
China
Contacts
Public ContactJie Ren
The Third Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed