Sepsis-associated Encephalopathy
Conditions
Interventions
Sepsis-associated Encephalopathy group/ Sepsis group:none
Sponsors
Affiliated Hangzhou First People’s Hospital, West Lake University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with sepsis: meet the diagnosis of sepsis 3.0 established by the "2016 International Conference on the Definition of Systemic Infection of the Society of Critical Care Medicine/European Society of Critical Care Medicine/American College of Chest Physicians/American Thoracic Society/Society of Surgical Infection" Criteria, which are defined as life-threatening organ dysfunction resulting from a dysregulated host response to infection. SAE patients: Doctors and nurses have clearly documented cognitive and neuropsychiatric disorders, as well as GCS<15 points, and delirium manifestations confirmed by the Confusion Assessment Method of the Intensive Care Unit (CAM-ICU) (such as attention Concentration, disorientation, thinking changes, psychomotor slowing, restlessness, etc.); SAE-specific EEG changes identified by amplitude-integrated electroencephalogram (aEEG)-based multimodal brain function monitoring technology: (1) Excessive increase of ? wave (low voltage, frequency generally greater than 4Hz, less than 8Hz); (2) delta wave dominant (medium to high voltage, frequency less than or equal to 4Hz); (3) three-phase wave (typical or atypical three-phase wave as the main (4) Inhibitory type (the active electrode is lower than 20 µV in the bipolar lead or reference lead mode, showing resting EEG), or burst-inhibitory type.
Exclusion criteria
Exclusion criteria: 1) Primary nervous system diseases include central nervous system infection (meningitis and encephalitis caused by various pathogenic microorganisms), cerebrovascular disease (cerebral hemorrhage, cerebral infarction, etc.), autoimmune encephalitis, epilepsy, etc.; 2 ) Non-nervous system diseases include metabolic diseases (for example, water and electrolyte disorders, hypoglycemia, diabetic ketoacidosis, hepatic encephalopathy, pulmonary encephalopathy, uremic encephalopathy, etc.); 3) rheumatic hematological diseases (such as hemolytic- uremic syndrome, systemic lupus erythematosus, etc.); 4) intoxication and withdrawal symptoms (such as alcohol, carbon monoxide, etc.); 5) changes in cognition and consciousness associated with analgesia and sedation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gastrointestinal microbes; | — |
Secondary
| Measure | Time frame |
|---|---|
| miRNA; | — |
Countries
China
Contacts
Public ContactXi Shaosong
Department of Critical Care Medicine, Affiliated Hangzhou First People’s Hospital, West Lake University School of Medicine
Outcome results
None listed