None listed
Conditions
Interventions
1:Four exposures were carried out in sequence: (1)ozone 200 ppb, 22?
(2) clean air, 22?
(3) Ozone 200 ppb, 32?
(4) clean air 32?. Thereby the "cross-over" process was achieved for heat and ozone exposure.
2:Four exposures were carried out in sequence: (1)clean air, 22?
(2) ozone 200 ppb, 22?
(3) clean air, 32?
(4) ozone 200 ppb, 32?.Thereby the "cross-over" process was achieved for heat and ozone exposure.
3:Four exposures were carried out in sequence:(1) ozone 200 ppb, 32?
(2) clean air, 32?
(3) Ozone 200 ppb, 22?
(4) clean air, 22?.Thereby the "cross-over" process was achieved for heat and ozone exposure.
4:Four exposures were carried out successively: (1)clean air, 32?
(2) ozone 200 ppb, 32?
(3) clean air, 22?
(4) ozone 200 ppb, 22?.Thereby the "cross-over" process was achieved for heat and ozone exposure.
Sponsors
College of Environmental Sciences and Engineering, Peking University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Participants will be aged 18 to 60 years, in good health, and with a gender ratio of 1:1.
Exclusion criteria
Exclusion criteria: Smokers (including electronic cigarettes) or those who have quit smoking for less than 3 years; individuals medically diagnosed with chronic cardiovascular diseases (such as ischemic heart disease), respiratory diseases (such as asthma or chronic obstructive pulmonary disease), diabetes, or other organ or system dysfunctions; those with active psychiatric disorders that interfere with their ability to understand and participate in the study, immune system diseases (such as HIV, lymphoma, leukemia), or a history of drug or alcohol abuse; individuals with a BMI >35 or <18; those who are planning to conceive, currently pregnant, or breastfeeding; individuals who have undergone major surgery in the past 5 years; those unable to provide blood samples; and individuals unable to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FeNO;FEV1, FVC, PEF;EBC MDA;exhaled VOCs;EBC pH;EBC NO2- NO3-;EBC Cytokines ((such as IL-6, TNFa, etc.); | — |
Secondary
| Measure | Time frame |
|---|---|
| serum Cytokines (such as IL-6, TNFa, etc.);SPO2;CRP;8-OHdG;Creatinine;Fibrinogen;Blood Pressure(SBP, DBP, PP);Pulse Wave Velocity (PWV);Reactive Hyperemia Index (RHI);Heart Rate Variability (HRV);Hormone(Epinephrine, Norepinephrine, etc.);Cognitive Function(reaction time, memory, etc. );Blood Sugar;Blood Lipids(TG, LDL-C, HDL-C, TC);Multi-omics Indicators(Transcriptomics, Epigenomics, DNA-adducts, Metabolomics, Microbiomics, Proteomics );blood cell counts;EEG;clotting factors;Stroke volume;insulin;glycosylated hemoglobin;Myocardial enzyme;urine MDA;Ejection fraction;Cerebral arterial blood flow velocity;transaminase;Skin moisture content and chromaticity; | — |
Countries
China
Contacts
Public ContactXinghua Qiu
College of Environmental Sciences and Engineering, Peking University
Outcome results
None listed