gastrointestinal disease
Conditions
Interventions
Group A:Nalbuphine hydrochloride combined with cyclopofol
Group B:Sufentanil combined with cyclopofol
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 75 years, regardless of gender; 2.Meet the indications for painless gastrointestinal endoscopy, such as requiring gastrointestinal endoscopy for the diagnosis or treatment of gastrointestinal diseases; 3.No history of allergies to relevant medications, especially no allergies to nalbuphine hydrochloride and cyclopropofol; 4.No severe cardiopulmonary diseases, such as heart failure, severe arrhythmias, severe respiratory diseases, etc.; 5.Basically normal liver and kidney function, with no history of severe liver or kidney dysfunction; 6.Able to understand and cooperate with the research requirements, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.History of severe cardiopulmonary diseases, such as heart failure, severe arrhythmias, severe respiratory diseases, etc.; 2.Hepatic and renal insufficiency, with a history of severe hepatic or renal diseases; 3.History of mental illnesses, such as epilepsy, schizophrenia, etc.; 4.Pregnant or lactating women; 5.Recent use of medications that may affect study results, such as analgesics, sedatives, antidepressants, etc.; 6.Inability to understand and cooperate with research requirements, such as language communication barriers, cognitive impairments, etc.; 7.Participation in any clinical trials as a subject within the past 3 months; 8.Other conditions deemed unsuitable for inclusion by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Discomfort score;Depth of sedation;Patients satisfaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions; | — |
Countries
China
Contacts
Public Contactyan zhenyi
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed