acute-on-chronic (subacute) liver failure
Conditions
Interventions
Observation group A:Traditional priming method + succinylated gelatin injection 500ml priming the adsorption column.
Observation group B:Traditional priming method + succinylated gelatin injection 500ml priming the adsorption column + succinylated gelatin injection 500ml priming the circuit.
Control Group C:Traditional priming method
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Age = 18 and < 70 years old, gender unspecified; 2) Meets the diagnostic criteria of the "Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)"; 3) Patients determined by the physician to have indications for DPMAS+PE treatment; 4) Voluntarily participates in this clinical trial and signs the informed consent form; 5) Systolic blood pressure < 90mmHg with no symptoms related to hypotension.
Exclusion criteria
Exclusion criteria: 1) Patients with severe active bleeding or disseminated intravascular coagulation; 2) Patients with a severe allergic reaction to blood products or medications used during the treatment process, such as plasma, heparin, protamine, etc.; 3) Patients in an unstable phase of myocardial infarction or cerebral infarction; 4) Patients who have participated in other clinical trials within the past month; 5) Patients deemed unsuitable for inclusion by the researcher for other reasons; 6) Patients with a history of severe allergies; 7) Patients allergic to gelatin injection; 8) Patients with circulatory overload, fluid retention, severe renal failure, bleeding tendency, or pulmonary edema; 9) Patients using terlipressin and pressor medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;adverse reaction; | — |
Countries
China
Contacts
Public ContactFang Chen
West China Hospital, Sichuan University
Outcome results
None listed