Cancer pain
Conditions
Interventions
Oxycodone/acetaminophen tables Group:analgesia with oxycodone/acetaminophen tables
Oxycodone hydrochloride sustained-release tablets Group:analgesia with oxycodone hydrochloride sustained-release tablets
Sponsors
Xiangyang No.1 People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) The subject voluntarily signs the informed consent for this experiment; 2) Patients with histologically or pathologically diagnosed malignant solid tumors (excluding non-solid tumors such as hematologic tumors and lymphomas) 3) Age 18-80 years old (including 18 and 80 years old), clear awareness, regardless of the sex; 4) Opioid intolerant patients with cancer pain and 4=NRS score < 7 in the last 24 hours 5) ECOG-PS =3 points;
Exclusion criteria
Exclusion criteria: 1) The patient is diagnosed with non-cancerous pain or unexplained pain; 2) Patients with paralytic ileus; 3) Patients with severe neuropathic cancer pain and other refractory cancer pain; 4) Severe liver and kidney dysfunction, such as creatinine = 2 of the upper limit of normal ALT or AST= 2.5 times the upper limit of normal (liver metastases Or primary liver cancer = 5 times the upper limit of normal), or liver function Child C grade; 5) Cognitive dysfunction; 6) Patients allergic to narcotic drugs; 7) Pregnant or lactating patients;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Titration success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS score 6h, 12h, 24h, 2d, 3d, 4d, 5d, 6d after the first treatment;Pain relief rate;Daily dose;Number of breakthrough pain;Satisfaction evaluation;quality of life; | — |
Countries
China
Contacts
Public ContactYouhong Dong
Xiangyang No.1 People’s Hospital
Outcome results
None listed