Circumcision in children
Conditions
Interventions
Esmketamine 0.5mg/kg group:Esketamine 0.5mg/kg was administered intravenously
Esmketamine 0.75mg/kg group:Esketamine 0.75mg/kg was administered intravenously
Esmketamine 1.00mg/kg group:Esketamine1.00mg/kg was administered intravenously
Esmketamine 1.25mg/kg group:Esketamine1.25mg/kg was administered intravenously
Esmketamine 1.50mg/kg group:Esketamine1.50mg/kg was administered intravenously
Sponsors
Wenling Maternity and Child Health Care Hospital
Eligibility
Sex/Gender
Male
Age
3 Years to 9 Years
Inclusion criteria
Inclusion criteria: American Society of Anesthesiologists ?-?, aged 3-9 years, with no history of systemic diseases, scheduled for circumcision under intravenous general anesthesia with esketamine.
Exclusion criteria
Exclusion criteria: (1) The children and their families refused to participate in the study; (2)ASA greater than grade ?; (3) allergy to esketamine or propofol; (3) patients with serious risk of hypertension, diabetes, hyperthyroidism, elevated intraocular pressure or intracranial pressure; (4) abnormal liver and kidney function; (5) current use of sedatives (propofol, morphine, fentanyl, sufentanil, midazolam, dexmedetomidine, ketamine) or recent use of sedatives (withdrawal time less than 24 hours).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of successful and unsuccessful cases for each dose of esketamine to prevent the occurrence of body movement during skin incision in children; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disappearance time of eyelash reflex after medication;Awake time;The hamodynamic situation;Common side effects include psychiatric symptoms, nausea, and vomiting; | — |
Countries
China
Contacts
Public ContactZhimin Sheng
Wenling Maternity and Child Health Care Hospital
Outcome results
None listed